Breast cancers are ER-positive, HER2-positive, or triple negative. The type of breast cancer you have determines the type of medication you take. Learn more from experts at WebMD.Author: Gina Shaw. Aug 16, 2019 · Estrogen receptors on the surface of breast cancer cells are Of course, being mistakenly diagnosed as HER2 positive if your tumor is HER2 negative could result in using HER2 directed medications, which may be ineffective for you (although some HER2 negative tumors have responded to Herceptin, which is the treatment used for HER2 positive.
Jun 07, 2016 · Breast cancers that have estrogen receptors are called ER-positive (or ER+). Those with progesterone receptors are referred to as PR-positive (or PR+). In addition to hormone receptors, some breast cancers have high levels of a growth-promoting protein called HER2/neu. If a tumor has this property, it is called HER2-positive. Sep 02, 2014 · The cancer is called HER2-negative when it does not have high levels of the HER2 gene or the HER2 protein. Most patients with metastatic breast cancer have HER2-negative breast cancer. If HER2-negative breast cancer is also hormone receptor positive, the most common treatment is hormonal therapy, but chemotherapy or targeted therapy may also be.
Breast cancers that are ER-positive tend to be PR-positive. And, cancers that are ER-negative tend to be PR-negative. Sometimes, a breast cancer is ER-positive, but PR-negative. Because current hormone therapies are designed to treat ER-positive cancers, these cases are treated the same as breast cancers that are positive for both hormone. INTRODUCTION. Triple-negative breast cancer (TNBC) is a term that has historically been applied to cancers that lack expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).