1 The effect of phenobarbitone on the single dose pharmacokinetics of the synthetic steroids, ethinyloestradiol (EE2) and norethisterone, has been studied in the rabbit and rat. 2 EE2 is subject to an extensive first pass effect (96%). The plasma clearance of EE2 approaches total hepatic blood flow.Cited by: 24. Effect of increased calcium intake on cardiac and vascular Na +-K+-ATPase activity in oral contraceptive-treated female Sprague-Dawley rats.
The use of estrogen–progestogen oral contraceptive (OC) is associated with high blood pressure, although mechanisms responsible are still unclear. This study sought to investigate the effects of administration of OC on high blood pressure resulting from nitric oxide (NO) synthesis inhibition in female Sprague–Dawley rats.Cited by: 6. C. Cardiac output is directly related to the heart rate and stroke volume. Changes in either variable affect the cardiac output. Preload is the pressure generated in the left ventricle at the end of diastole (end-diastolic volume). Afterload is the resistance or impedance to the ejection of .
Oral contraceptive-induced high blood pressure is prevented by renin-angiotensin suppression in female rats but not by sympathetic nervous system blockade L A Olatunji & A O Soladoye Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515, . Oral contraceptive use and the risk of cardiac events in patients with long QT syndrome. To study the effect of oral contraceptive use on the risk of CEs in patients with LQTS. We studied 174 patients from the Rochester-based LQTS Registry who responded to a questionnaire about their oral contraceptive Cited by: 6.